BDBM708442 3-(2,4-difluorophenyl)-3- hydroxy-4-(1H-1,2,4-triazol-1- yl)butyl 2-(4-(((3-amino-2-oxo- 1-(4-phenyl-3,4-dihydro-2H- benzo[b][1,4]oxazin-6-yl)-1,2- dihydrothieno[2,3-b]pyrazin-6- yl)methyl)amino)piperidin-1- yl)acetate::US20240424113, Compound I-136

SMILES Nc1nc2sc(CNC3CCN(CC(=O)OCCC(O)(Cn4cncn4)c4ccc(F)cc4F)CC3)cc2n(-c2ccc3c(c2)N(c2ccccc2)CCO3)c1=O

InChI Key InChIKey=NXXFAHOQTCAROX-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 708442   

TargetHeat shock protein 90 homolog(Yeast)
Bright Angel Therapeutics

US Patent
LigandPNGBDBM708442(3-(2,4-difluorophenyl)-3- hydroxy-4-(1H-1,2,4-tria...)
Affinity DataKd:  271nMAssay Description:Surface Plasmon Resonance (SPR) Experiments. SPR experiments were performed on a Biacore S200 instrument at 25° C. Biotinylated Hsp90 Nuclear Binding...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent

TargetHeat shock protein 90(Neosartorya fumigata)
Bright Angel Therapeutics

US Patent
LigandPNGBDBM708442(3-(2,4-difluorophenyl)-3- hydroxy-4-(1H-1,2,4-tria...)
Affinity DataKd:  529nMAssay Description:Surface Plasmon Resonance (SPR) Experiments. SPR experiments were performed on a Biacore S200 instrument at 25° C. Biotinylated Hsp90 Nuclear Binding...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent