BDBM709006 (S)-7'-(3,5-difluorophenyl)- 1-(7-methylquinolin-4- yl)dihydro-l'H,3'H,5'H- spiro[piperidine-4,2'- pyrazolo[1,2-a]pyrazol]-1'- one::US20240425524, Example 2.8

SMILES Cc1ccc2c(N3CCC4(CC3)CN3CC[C@@H](c5cc(F)cc(F)c5)N3C4=O)ccnc2c1

InChI Key InChIKey=HEECPVJGGKUSBG-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 709006   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 709006BDBM709006((S)-7'-(3,5-difluorophenyl)- 1-(7-methylquinolin-4...)
Affinity DataEC50:  24nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution: top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent