BDBM70921 BDBM70996::US9546164, 146::US9694002, 87

SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3ccccc3)CC2)cc1F

InChI Key InChIKey=YGCDGFNMFBCJAB-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 70921   

LigandPNGBDBM70921(BDBM70996 | US9694002, 87 | US9546164, 146)
Affinity DataIC50: 278nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

LigandPNGBDBM70921(BDBM70996 | US9694002, 87 | US9546164, 146)
Affinity DataIC50: 276nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70921(BDBM70996 | US9694002, 87 | US9546164, 146)
Affinity DataIC50: 278nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70921(BDBM70996 | US9694002, 87 | US9546164, 146)
Affinity DataIC50: 276nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 7 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70921(BDBM70996 | US9694002, 87 | US9546164, 146)
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 7 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70921(BDBM70996 | US9694002, 87 | US9546164, 146)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 1 hr in presence of veratridine by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70921(BDBM70996 | US9694002, 87 | US9546164, 146)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 1 hr in presence of veratridine and anthropleurin-C by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed