BDBM70937 US9546164, 100::US9694002, 100

SMILES C[C@@H](c1cc(cc(c1)Cl)Cl)N2CCC(CC2)COc3cc(c(cc3C4CC4)C(=O)NS(=O)(=O)C)F

InChI Key InChIKey=SXOAHIZWCZOILH-UHFFFAOYSA-N

Data  20 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 70937   

TargetSodium channel protein type 7 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length human Nav1.7 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 551nMAssay Description:Inhibition of human Nav1.5/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 202nMAssay Description:Inhibition of human Nav1.1/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSodium channel subunit beta-2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 198nMAssay Description:Inhibition of human Nav1.6 expressed in CHO cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 551nMAssay Description:Inhibition of full length human Nav1.5 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 38nMAssay Description:Inhibition of full length human Nav1.2 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 202nMAssay Description:Inhibition of full length human Nav1.1 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 4.20nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 1 hr in presence of veratridine and anthropleurin-C by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 7 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 1 hr in presence of veratridine by sodium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 7 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 552nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 5.80nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 4.19nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 4.10nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 552nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 5.80nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent