BDBM712795 US20250017936, Compound 5m

SMILES C#CCN(CC#Cc1cccc(C(N)=O)c1)CC1C[C@@H](n2ccc3c(Cl)ncnc32)[C@H](O)[C@@H]1O

InChI Key InChIKey=HTSMBIPYTSOCAS-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 712795   

TargetNicotinamide N-methyltransferase(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM712795(US20250017936, Compound 5m)
Affinity DataIC50: 30nMAssay Description: As the sensitivity of the FAP assay is limited by the binding affinity of the probe for NNMT, the inhibitory concentration was further determined us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent

TargetNicotinamide N-methyltransferase(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM712795(US20250017936, Compound 5m)
Affinity DataKi:  56nMAssay Description:The inhibitory constants (Ki) of the synthesized inhibitors were first determined using a fluorescence polarization (FP)-based competition assay with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
Go to US Patent