BDBM713782 US12202835, Example 18

SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(OC)ccn(-c5ccc(F)cc5)c4=O)cc3F)c2c2c1OCCO2

InChI Key InChIKey=CVHRBRYPESWCSE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 713782   

TargetHigh affinity nerve growth factor receptor(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM713782(US12202835, Example 18)
Affinity DataIC50: 50nMAssay Description:TRKA Kinase: The assay of small molecular compounds for inhibiting the activity of TRKA kinase is based on the LANCE TR-FRET technology of Perkin Elm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
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TargetHepatocyte growth factor receptor(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM713782(US12202835, Example 18)
Affinity DataIC50: 50nMAssay Description:c-MET Kinase: The assay is based on the LANCE TR-FRET technology of Perkin Elmer Inc., and the assay method is as follows:1. Dilution of compounds: a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM713782(US12202835, Example 18)
Affinity DataIC50: 50nMAssay Description:MER Kinase: The assay of small molecular compounds for inhibiting the activity of MER kinase is based on the LANCE TR-FRET technology of Perkin Elmer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM713782(US12202835, Example 18)
Affinity DataIC50: 50nMAssay Description:VEGFR-2 Kinase: The assay is based on the LANCE TR-FRET technology of Perkin Elmer Inc., and the assay method is as follows:1. Dilution of compounds:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent