BDBM716125 5-bromo-N-pyrimidin-4-yl-6- [rac-(1S,2S,4S)-2-(dimethyl- amino)-4-[3-(trifluoromethyl)- phenyl]cyclohexoxy]pyridine- 3-sulfonamide formate salt::US12209075, Example 20::US20250115576, Example 20

SMILES CN(C)[C@H]1C[C@@H](c2cccc(C(F)(F)F)c2)CC[C@@H]1Oc1ncc(S(=O)(=O)Nc2ccncn2)cc1Br

InChI Key InChIKey=WMTPBQYTAPGMNQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 716125   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716125(5-bromo-N-pyrimidin-4-yl-6- [rac-(1S,2S,4S)-2-(dim...)
Affinity DataIC50: 0.900nMAssay Description:Sodium currents are measured in the whole-cell configuration using Syncropatch 384PE (Hanlon Technologies, Germany). 1NPC®-384 chips with custom medi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716125(5-bromo-N-pyrimidin-4-yl-6- [rac-(1S,2S,4S)-2-(dim...)
Affinity DataIC50: 28.2nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716125(5-bromo-N-pyrimidin-4-yl-6- [rac-(1S,2S,4S)-2-(dim...)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent