BDBM716154 6-(((1S,2S,4S)-4-(3-chloro-5- (trifluoromethyl)phenyl)-2- (dimethylamino)cyclohexyl)- oxy)-2-methyl-N-(pyrimidin- 4-yl)pyridine-3-sulfonamide::US12209075, Example 49::US20250115576, Example 49

SMILES Cc1nc(O[C@H]2CC[C@H](c3cc(Cl)cc(C(F)(F)F)c3)C[C@@H]2N(C)C)ccc1S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=NRZVXYUQQOJUNU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 716154   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716154(6-(((1S,2S,4S)-4-(3-chloro-5- (trifluoromethyl)phe...)
Affinity DataIC50: 0.188nMAssay Description:Sodium currents are measured in the whole-cell configuration using Syncropatch 384PE (Hanlon Technologies, Germany). 1NPC®-384 chips with custom medi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716154(6-(((1S,2S,4S)-4-(3-chloro-5- (trifluoromethyl)phe...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716154(6-(((1S,2S,4S)-4-(3-chloro-5- (trifluoromethyl)phe...)
Affinity DataIC50: 0.188nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
Go to US Patent