BDBM716973 N-[2-chloro-4-(trifluoromethyl)phenyl]-2-{2-[(1E)-2- cyclobutylethenyl]-6-ethyl-7-[4-(5-hydroxy-6-methylpyrimidine-4- carbonyl)piperazin-1-yl]-8-oxo-5H,8H-pyrido[2,3-b]pyrazin-5- yl}acetamide::US20250034136, Compound I-144

SMILES CCc1c(N2CCN(C(=O)c3ncnc(C)c3O)CC2)c(=O)c2nc(/C=C/C3CCC3)cnc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl

InChI Key InChIKey=YGFNRJNLIFDMIG-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 716973   

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1235,L1074F](Human)
Nimbus Wadjet

US Patent

LigandBDBM716973(N-[2-chloro-4-(trifluoromethyl)phenyl]-2-{2-[(1E)-...)Copy SMILESCopy InChI

Affinity DataIC50: 5nMAssay Description:Bovine skin gelatin (BSG), dimethyl sulfoxide (DMSO), Pluronic F-127 and tris(2-carboxyethyl)phosphine hydrochloride solution (TCEP) were purchased f...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
6/5/2025
Entry Details
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