BDBM717221 (1s,3s)-3-{[3-(4-fluorophenyl)- 4-(6-phenylfuro[2,3-d]pyrimidin- 4-yl)-1H-pyrazol-1- yl]methyl}cyclobutan-1-ol::US20250034159, Example 42

SMILES O[C@H]1C[C@@H](Cn2cc(-c3ncnc4oc(-c5ccccc5)cc34)c(-c3ccc(F)cc3)n2)C1

InChI Key InChIKey=FOBFFUXZOKPTHZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 717221   

TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717221((1s,3s)-3-{[3-(4-fluorophenyl)- 4-(6-phenylfuro[2,...)
Affinity DataIC50: 0.335nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR exon 19 deletion/C7...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM717221((1s,3s)-3-{[3-(4-fluorophenyl)- 4-(6-phenylfuro[2,...)
Affinity DataIC50: 0.527nMAssay Description:The inhibitory activity of the compounds disclosed herein were measured in a biochemical assay utilizing a recombinant human EGFR L858R/C797S double ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent