BDBM719099 US20250049809, Example 3

SMILES C=CC(=O)N1CCN(C2CCCC/C=C/CN3C(=O)OCc4cnc(nc43)N[C@@H](C)c3ccc2cc3)CC1

InChI Key InChIKey=WONPVHSSMXTIOP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 719099   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H,S280F](Human)
University Of Texas

US Patent
LigandPNGBDBM719099(US20250049809, Example 3)
Affinity DataIC50: 260nMAssay Description:The enzymatic activity of mIDH1R132H/S280F was assessed by measuring the fluorescence of the NADPH. The assay was performed in 384 well, white ProxiP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial [R140Q](Human)
University Of Texas

US Patent
LigandPNGBDBM719099(US20250049809, Example 3)
Affinity DataIC50: 1.44E+3nMAssay Description:The enzymatic activity of mIDH2R140Q was assessed by measuring the fluorescence of the NADPH. The assay was performed in 384 well, white ProxiPlates ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
University Of Texas

US Patent
LigandPNGBDBM719099(US20250049809, Example 3)
Affinity DataIC50: 3.30nMAssay Description:The enzymatic activity of mIDH1R132H was assessed by measuring the fluorescence of the NADPH. The assay was performed in 384 well, white ProxiPlates ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
University Of Texas

US Patent
LigandPNGBDBM719099(US20250049809, Example 3)
Affinity DataIC50: 3.17E+3nMAssay Description:The enzymatic activity of WT IDH1 was assessed by measuring the fluorescence of the NADPH generated in the enzymatic reaction. The assay was performe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
University Of Texas

US Patent
LigandPNGBDBM719099(US20250049809, Example 3)
Affinity DataIC50: 1.62E+4nMAssay Description:The enzymatic activity of WT IDH2 was assessed by measuring the fluorescence of the NADPH generated in the enzymatic reaction. The assay was performe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
Go to US Patent