BDBM72118 5-isopropyl-N-(2-(1-methyl-1H-pyrazol-4-yl)pyrimidin-4-yl)-8-((2R,3S)-2-methyl-3-((methanesulfonyl)methyl)azetidin-1-yl)isoquinolin-3-amine::US20250368616, Example 24

SMILES CC(C)c1ccc(N2C[C@H](CS(C)(=O)=O)[C@H]2C)c2cnc(Nc3ccnc(-c4cnn(C)c4)n3)cc12

InChI Key InChIKey=PGZZJKIGLNOHBC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 72118   

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Shanghai Hansoh Biomedical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 72118BDBM72118(5-isopropyl-N-(2-(1-methyl-1H-pyrazol-4-yl)pyrimid...)
Affinity DataIC50: 0.300nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Shanghai Hansoh Biomedical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 72118BDBM72118(5-isopropyl-N-(2-(1-methyl-1H-pyrazol-4-yl)pyrimid...)
Affinity DataIC50: 3.60nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2026
Entry Details
US Patent