BDBM72189 4,6-Dimethyl-3-(3-naphthalen-1-yl-acryloyl)-1H-pyridin-2-one::4,6-dimethyl-3-[(E)-3-(1-naphthalenyl)-1-oxoprop-2-enyl]-1H-pyridin-2-one::4,6-dimethyl-3-[(E)-3-(1-naphthyl)acryloyl]-2-pyridone::4,6-dimethyl-3-[(E)-3-naphthalen-1-ylprop-2-enoyl]-1H-pyridin-2-one::MLS000553813::SMR000171433::cid_5719932

SMILES C[C@@H](NC(=O)c1cc(N2CCOCC2)c(C#N)cc1N[C@H]1CN2CCC1CC2)c1cccc(C(F)F)c1F

InChI Key InChIKey=LTUAOGFECIPAMP-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 72189   

TargetGTPase KRas [1-169,G12C](Human)
SchroDinger

US Patent
LigandChemical structure of BindingDB Monomer ID 72189BDBM72189(US20250368634, Example 24)
Affinity DataIC50: 22.7nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2026
Entry Details
US Patent