BDBM7242 (3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-yl}methylidene)-N-(propan-2-yl)-2,3-dihydro-1H-indole-5-sulfonamide::pyrrollylactone indolinone driv. 15d

SMILES CC(C)NS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1

InChI Key InChIKey=FNZUUGCKBYLYMM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7242   

LigandPNGBDBM7242((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...)
Affinity DataIC50: 64nMpH: 7.4 T: 2°CAssay Description:For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2006
Entry Details Article
PubMed
LigandPNGBDBM7242((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...)
Affinity DataIC50: 6.70E+3nMT: 2°CAssay Description:For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2006
Entry Details Article
PubMed
LigandPNGBDBM7242((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...)
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2006
Entry Details Article
PubMed
LigandPNGBDBM7242((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...)
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2006
Entry Details Article
PubMed