BDBM725168 4-((2'R,3R,4'R,5'S)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-neopentylspiro[indoline-3,3'-pyrrolidine]-5'-carbonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide::US20250073340, Example 15

SMILES CC(C)(C)C[C@H]1N[C@H](C(=O)N2CCOc3cc(C(N)=O)ccc32)[C@@H](c2cccc(Cl)c2F)[C@@]12CNc1cc(Cl)ccc12

InChI Key InChIKey=IQUGDBQAOOBUAJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 725168   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Newave Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 725168BDBM725168(4-((2'R,3R,4'R,5'S)-6-chloro-4'-(3-chloro-2-fluoro...)
Affinity DataIC50: 638nMAssay Description:The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/9/2025
Entry Details
US Patent