BDBM7363 6-(4-methoxyphenyl)-7-(prop-2-en-1-yl)-5H-pyrrolo[2,3-b]pyrazine::6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 34::7-Allyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine

SMILES COc1ccc(cc1)-c1[nH]c2nccnc2c1CC=C

InChI Key InChIKey=RYNPAHUWYURCCW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7363   

TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Faculte De Medecine Et De Pharmacie

LigandPNGBDBM7363(7-Allyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyraz...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Faculte De Medecine Et De Pharmacie

LigandPNGBDBM7363(7-Allyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyraz...)
Affinity DataIC50: 600nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Faculte De Medecine Et De Pharmacie

LigandPNGBDBM7363(7-Allyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyraz...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM7363(7-Allyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyraz...)
Affinity DataIC50: 603nMAssay Description:Inhibitory concentration against Glycogen synthase kinase-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed