BDBM74795 2-Amino-4-(5-methyl-thiophen-2-yl)-5,6,7,8-tetrahydro-quinoline-3-carbonitrile::2-amino-4-(5-methyl-2-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-4-(5-methyl-2-thiophenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-4-(5-methylthiophen-2-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-azanyl-4-(5-methylthiophen-2-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::CA inhibitor, 5b::MLS000563329::SMR000175799::cid_794068

SMILES Cc1ccc(s1)-c1c2CCCCc2nc(N)c1C#N

InChI Key InChIKey=PXPKBHQSIDCTMM-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 74795   

TargetImportin subunit alpha-1(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM74795(2-azanyl-4-(5-methylthiophen-2-yl)-5,6,7,8-tetrahy...)
Affinity DataEC50:  2.71E+4nMAssay Description:Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2011
Entry Details
PCBioAssay
TargetCarbonic anhydrase 1(Human)
Gazi University

LigandPNGBDBM74795(2-azanyl-4-(5-methylthiophen-2-yl)-5,6,7,8-tetrahy...)
Affinity DataKi:  3.10E+4nM IC50: 3.40E+4nMpH: 7.4Assay Description:CA activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a period of 3 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Gazi University

LigandPNGBDBM74795(2-azanyl-4-(5-methylthiophen-2-yl)-5,6,7,8-tetrahy...)
Affinity DataKi:  1.82E+5nM IC50: 9.90E+4nMpH: 7.4Assay Description:CA activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a period of 3 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed