BDBM752413 US20250197405, Compound 12-P2

SMILES Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2c(=O)n(CF)c(C)nc21

InChI Key InChIKey=WYMHUHYVZWZYSY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 752413   

LigandChemical structure of BindingDB Monomer ID 752413BDBM752413(US20250197405, Compound 12-P2)
Affinity DataIC50: 1.5nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 752413BDBM752413(US20250197405, Compound 12-P2)
Affinity DataIC50: 1.60nMAssay Description:Binding affinity to recombinant human PKMYT1 incubated for15 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752413BDBM752413(US20250197405, Compound 12-P2)
Affinity DataIC50: 62nMAssay Description:Inhibition of CDK1 phosphorylation in human HCC1569 cells incubated for 6 hrs by In-cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 752413BDBM752413(US20250197405, Compound 12-P2)
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human WEE1 preincubated with compound for 15 mins followed by ATP addition and measured after 60 mins ADP-GLO luminescent a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed