BDBM754033 US20250206761, Example RM461-A

SMILES CCn1c(-c2cccnc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CN(C(=O)[C@@H](F)Cl)C1)C(=O)N1CCCC(N1)C(=O)OCC(C)(C)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 754033   

LigandPNGBDBM754033(US20250206761, Example RM461-A)
Affinity DataIC50: 27nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/20/2025
Entry Details
US Patent

LigandPNGBDBM754033(US20250206761, Example RM461-A)
Affinity DataIC50: 6.08E+3nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/20/2025
Entry Details
US Patent

LigandPNGBDBM754033(US20250206761, Example RM461-A)
Affinity DataIC50: 1.00E+4nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/20/2025
Entry Details
US Patent