BDBM764448 3-((2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamido)pyridine 1-oxide::US20250255878, Compound TM2-16

SMILES COc1c([C@H]2[C@H](C(=O)NC3C=[N+]([O-])C=CC3)O[C@@](C)(C(F)(F)F)[C@H]2C)ccc(F)c1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 764448   

TargetSodium channel protein type 10 subunit alpha(Human)
Humanwell Pharmaceutical US

US Patent
LigandPNGBDBM764448(3-((2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 1.34nMAssay Description:The Nav1.8 current is evoked by a 20 ms step voltage pulse to −10 mV from a holding potential of −80 mV at every 10 sec. The maximum amount of peak c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/24/2025
Entry Details
US Patent