BDBM766936 3-(dimethylamino)-N-[(1S)-1-[[(7S,13S)-24-fluoro-(20M)-20-[2-[(1S)-1-methoxyethyl]-5-(4-methylpiperazin-1-yl)-3-pyridyl]-17,17-dimethyl-8,14-dioxo-21-(2,2,2-trifluoroethyl)-15-oxa-4-thia-9,21,27,28-tetrazapentacyclo[17.5.2.12,5.19,13.022,26]octacosa-1(25),2,5 (28),19,22 ::US20250268894, Example 1

SMILES CO[C@@H](C)c1ncc(N2CCN(C)CC2)cc1-c1c2c3cc(c(F)cc3n1CC(F)(F)F)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 766936   

TargetGTPase KRas [G12C]/Serine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM766936(3-(dimethylamino)-N-[(1S)-1-[[(7S,13S)-24-fluoro-(...)
Affinity DataIC50: 46nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

TargetTPase KRas [G12V]/Serine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM766936(3-(dimethylamino)-N-[(1S)-1-[[(7S,13S)-24-fluoro-(...)
Affinity DataIC50: 70nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

TargetTPase KRas [G12D]/Serine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM766936(3-(dimethylamino)-N-[(1S)-1-[[(7S,13S)-24-fluoro-(...)
Affinity DataIC50: 147nMAssay Description:In this example, TR-FRET was also used to measure the compound or compound-CYPA dependent disruption of the KRAS G12C-BRAF complex. This protocol was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent