BDBM771648 Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl)phenyl)-8-(1- isopropyl-1H- indazol-5-yl)-3- (methyl-d3)-2-oxo- 3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 26

SMILES [2H]C([2H])([2H])n1c(=O)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c2c3c(-c4ccc5c(cnn5C(C)C)c4)c(-c4ccc(CN(C)C)cc4)[nH]c3ncc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 771648   

LigandPNGBDBM771648(Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte

US Patent
LigandPNGBDBM771648(Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl...)
Affinity DataIC50: 750nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM771648(Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM771648(Methyl ((1R,3R)-3- (7-(4- ((dimethylamino)meth- yl...)
Affinity DataIC50: 1.88E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent