BDBM771649 Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)methyl)phe- nyl)-8-(4-(2- methoxyethoxy)phe- nyl)-3-(methyl-d3)- 2-oxo-3,6- dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-1(2H)- yl)cyclopentyl)carba- mate::US20250092044, Example 27

SMILES [2H]C([2H])([2H])N(Cc1ccc(-c2[nH]c3ncc4c(c3c2-c2ccc(OCCOC)cc2)n([C@@H]2CC[C@@H](NC(=O)OC)C2)c(=O)n4C([2H])([2H])[2H])cc1)C([2H])([2H])[2H]

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 771649   

LigandPNGBDBM771649(Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)me...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte

US Patent
LigandPNGBDBM771649(Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)me...)
Affinity DataIC50: 750nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM771649(Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)me...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Incyte

US Patent
LigandPNGBDBM771649(Methyl ((1R,3R)-3- (7-(4-((bis(methyl- d3)amino)me...)
Affinity DataIC50: 1.88E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/31/2025
Entry Details
US Patent