BDBM774921 (E)-3-(4-(((1- (3',6-Dicyano-5'- (2-fluoro-5- hydroxy-4- methoxyphenyl)- [3,4'-bipyridin]- 2'-yl)piperidin-4- yl)amino)methyl) phenyl)-N- hydroxyacrylamide formate::US20250304549, Example 255

SMILES COc5cc(F)c(c3cnc(N2CCC(NCc1ccc(/C=C/C(=O)NO)cc1)CC2)c(C#N)c3c4ccc(C#N)nc4)cc5O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 774921   

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774921BDBM774921((E)-3-(4-(((1- (3',6-Dicyano-5'- (2-fluoro-5- hydr...)
Affinity DataIC50: 0.680nMAssay Description:The effect of the compound on the enzymatic activity of pan-HDAC and two isoforms (HDAC1 and HDAC8) was examined using the HDAC-Glo I/II Assay and Sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Sichuan Huiyu Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 774921BDBM774921((E)-3-(4-(((1- (3',6-Dicyano-5'- (2-fluoro-5- hydr...)
Affinity DataIC50: 1.54nMAssay Description:The effect of the compounds on LSD1 enzyme activity was examined using the HTRF technique to assess the level of inhibition. Initially, a master solu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent