BDBM783269 2,4-bis(((S)-4- (((2R,5R)-1-(2-(6-(4- fluorobenzyl)-3,3- dimethyl-5-oxo- 2,3,4,5-tetrahydro-1H- pyrrolo[3,2-b]pyridin- 1-yl)-2-oxoethyl)-5- methylpiperazin-2- yl)methyl)morpholin-2- yl)methoxy)benzonitrile::US20250326771, Compound 77

SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3[nH]c(=O)c(Cc4ccc(F)cc4)cc32)[C@@H](CN2CCO[C@H](COc3ccc(C#N)c(OC[C@@H]4CN(C[C@H]5CN[C@H](C)CN5CC(=O)N5CC(C)(C)c6[nH]c(=O)c(Cc7ccc(F)cc7)cc65)CCO4)c3)C2)CN1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 783269   

TargetBaculoviral IAP repeat-containing protein 3 [255-322](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783269BDBM783269(2,4-bis(((S)-4- (((2R,5R)-1-(2-(6-(4- fluorobenzyl...)
Affinity DataIC50: 5.35nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 2 [269-336](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783269BDBM783269(2,4-bis(((S)-4- (((2R,5R)-1-(2-(6-(4- fluorobenzyl...)
Affinity DataIC50: 5.35nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase XIAP [265-330](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783269BDBM783269(2,4-bis(((S)-4- (((2R,5R)-1-(2-(6-(4- fluorobenzyl...)
Affinity DataIC50: 31.6nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 3 [169-235](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783269BDBM783269(2,4-bis(((S)-4- (((2R,5R)-1-(2-(6-(4- fluorobenzyl...)
Affinity DataIC50: 2.58E+3nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 2 [184-250](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783269BDBM783269(2,4-bis(((S)-4- (((2R,5R)-1-(2-(6-(4- fluorobenzyl...)
Affinity DataIC50: 2.58E+3nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase XIAP [163-230](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783269BDBM783269(2,4-bis(((S)-4- (((2R,5R)-1-(2-(6-(4- fluorobenzyl...)
Affinity DataIC50: 3.57E+4nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent