BDBM783811 (1R,3R)-8-[3-(4-chloro-2- methyl- 2H-indazol-5-yl)-5- methyl-1H- pyrazolo[3,4-b]pyrazin- 6-yl]-3- (trifluoromethyl)-8- azaspiro[4.5]decan-1- amine hydrochloride::US12458640, Example 1

SMILES Cc1nc2c(-c3ccc4nn(C)cc4c3Cl)n[nH]c2nc1N1CCC2(CC1)C[C@@H](C(F)(F)F)C[C@H]2N

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 783811   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 783811BDBM783811((1R,3R)-8-[3-(4-chloro-2- methyl- 2H-indazol-5-yl)...)
Affinity DataIC50: 20nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/24/2026
Entry Details US Patent