BDBM784723 ((6-(4-(2-hydroxyethyl)piperazin- 1-yl)-2- methylpyrimidin-4- yl)amino)-N-phenylthiazole-5- carboxamide::US20250340886, Compound A11

SMILES Cc1nc(Nc2ncc(C(=O)Nc3ccccc3)s2)cc(N2CCN(CCO)CC2)n1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 784723   

TargetSerine/threonine-protein kinase SIK2(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784723BDBM784723(((6-(4-(2-hydroxyethyl)piperazin- 1-yl)-2- methylp...)
Affinity DataIC50: 100nMAssay Description:Table 2A: Indicative IC50s for compounds synthesised in Table 1 were determined against each of SIK1, SIK2 and SIK3 using a biochemical assay for SIK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784723BDBM784723(((6-(4-(2-hydroxyethyl)piperazin- 1-yl)-2- methylp...)
Affinity DataIC50: 100nMAssay Description:Table 2A: Indicative IC50s for compounds synthesised in Table 1 were determined against each of SIK1, SIK2 and SIK3 using a biochemical assay for SIK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784723BDBM784723(((6-(4-(2-hydroxyethyl)piperazin- 1-yl)-2- methylp...)
Affinity DataIC50: 1.00E+3nMAssay Description:Table 2A: Indicative IC50s for compounds synthesised in Table 1 were determined against each of SIK1, SIK2 and SIK3 using a biochemical assay for SIK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent