BDBM784728 N-(2,6-dibromophenyl)-2- ((6-(4-(2-hydroxyethyl)piperazin- 1-yl)-2-methylpyrimidin-4- yl)amino)thiazole-5- carboxamide::US20250340886, Compound B2

SMILES Cc1nc(Nc2ncc(C(=O)Nc3c(Br)cccc3Br)s2)cc(N2CCN(CCO)CC2)n1

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 784728   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784728BDBM784728(N-(2,6-dibromophenyl)-2- ((6-(4-(2-hydroxyethyl)pi...)
Affinity DataIC50: 100nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784728BDBM784728(N-(2,6-dibromophenyl)-2- ((6-(4-(2-hydroxyethyl)pi...)
Affinity DataIC50: 100nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784728BDBM784728(N-(2,6-dibromophenyl)-2- ((6-(4-(2-hydroxyethyl)pi...)
Affinity DataIC50: 100nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784728BDBM784728(N-(2,6-dibromophenyl)-2- ((6-(4-(2-hydroxyethyl)pi...)
Affinity DataIC50: 100nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784728BDBM784728(N-(2,6-dibromophenyl)-2- ((6-(4-(2-hydroxyethyl)pi...)
Affinity DataIC50: 100nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent