BDBM784730 N-(3-fluoro-2-methoxyphenyl)-2- ((6-(4-(2- hydroxyethyl)piperazin-1-yl)-2- methylpyrimidin-4- yl)amino)thiazole-5-carboxamide::US20250340886, Compound B4

SMILES COc1c(F)cccc1NC(=O)c1cnc(Nc2cc(N3CCN(CCO)CC3)nc(C)n2)s1

InChI Key

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 784730   

TargetSerine/threonine-protein kinase SIK1(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784730BDBM784730(N-(3-fluoro-2-methoxyphenyl)-2- ((6-(4-(2- hydroxy...)
Affinity DataIC50: 100nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784730BDBM784730(N-(3-fluoro-2-methoxyphenyl)-2- ((6-(4-(2- hydroxy...)
Affinity DataIC50: 100nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784730BDBM784730(N-(3-fluoro-2-methoxyphenyl)-2- ((6-(4-(2- hydroxy...)
Affinity DataIC50: 100nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784730BDBM784730(N-(3-fluoro-2-methoxyphenyl)-2- ((6-(4-(2- hydroxy...)
Affinity DataIC50: 100nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
iOMx Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 784730BDBM784730(N-(3-fluoro-2-methoxyphenyl)-2- ((6-(4-(2- hydroxy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Table 4: Briefly, a radiometric protein kinase assay (33PanQinase® Activity Assay) was used for measuring the kinase activity of the five protein kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/26/2026
Entry Details
US Patent