BDBM785945 (1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-2-((9,9- difluoro-9H-fluorene-3- carbonyl)glycyl)-5-((2- (dimethylamino)ethoxy) methyl)-2- azabicyclo[3.1.0]hexane- 3-carboxamide::US20250346585, Compound 367

SMILES C[C@@H](NC(=O)[C@@H]1C[C@]2(COCCN(C)C)C[C@@H]2N1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(F)F)c1cc(C(=N)N)cs1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 785945   

TargetComplement C1s subcomponent(Human)
Alexion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 785945BDBM785945((1S,3S,5R)-N-((R)-1-(4- carbamimidoylthiophen- 2-y...)
Affinity DataIC50: 100nMAssay Description:Human complement C1s enzyme (purified from human serum, Complement Technology, Inc.) at 1.16 nM final concentration was incubated with test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent