BDBM785989 (2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 1-((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-4- fluoro-4- (fluoromethyl) pyrrolidine-2- carboxamide::US20250346585, Compound 398

SMILES N=C(N)c1csc([C@@H](CO)NC(=O)[C@@H]2C[C@](F)(CF)CN2C(=O)CNC(=O)c2ccc3c(c2)-c2ccccc2C3(F)F)c1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 785989   

TargetComplement C1s subcomponent(Human)
Alexion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 785989BDBM785989((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-...)
Affinity DataIC50: 100nMAssay Description:Human complement C1s enzyme (purified from human serum, Complement Technology, Inc.) at 1.16 nM final concentration was incubated with test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent