BDBM785990 (S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hydroxyethyl)- 7-((9,9-dimethyl-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 399

SMILES CC1(C)c2ccccc2-c2cc(C(=O)NCC(=O)N3CC4(C[C@H]3C(=O)N[C@H](CO)c3cc(C(=N)N)cs3)OCCO4)ccc21

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 785990   

TargetComplement C1s subcomponent(Human)
Alexion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 785990BDBM785990((S)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)-2-hy...)
Affinity DataIC50: 100nMAssay Description:Human complement C1s enzyme (purified from human serum, Complement Technology, Inc.) at 1.16 nM final concentration was incubated with test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent