BDBM786010 (2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)ethyl)-4-fluoro-4- (fluoromethyl)-1-((9- methyl-9H-fluorene-3- carbonyl)glycyl) pyrrolidine-2- carboxamide::US20250346585, Compound 417

SMILES C[C@@H](NC(=O)[C@@H]1C[C@](F)(CF)CN1C(=O)CNC(=O)c1ccc2c(c1)-c1ccccc1C2(C)C)c1cc(C(=N)N)cs1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 786010   

TargetComplement C1s subcomponent(Human)
Alexion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 786010BDBM786010((2S,4R)-N-((R)-1-(4- carbamimidoylthiophen- 2-yl)e...)
Affinity DataIC50: 100nMAssay Description:Human complement C1s enzyme (purified from human serum, Complement Technology, Inc.) at 1.16 nM final concentration was incubated with test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent