BDBM786017 (S)-N-((4- carbamimidoyl-1H- pyrrol-2-yl)methyl)-7- ((9,9-difluoro-9H- fluorene-3- carbonyl)glycyl)-1,4- dioxa-7- azaspiro[4.4]nonane-8- carboxamide::US20250346585, Compound 423

SMILES N=C(N)c1c[nH]c(CNC(=O)[C@@H]2CC3(CN2C(=O)CNC(=O)c2ccc4c(c2)-c2ccccc2C4(F)F)OCCO3)c1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 786017   

TargetComplement C1s subcomponent(Human)
Alexion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 786017BDBM786017((S)-N-((4- carbamimidoyl-1H- pyrrol-2-yl)methyl)-7...)
Affinity DataIC50: 100nMAssay Description:Human complement C1s enzyme (purified from human serum, Complement Technology, Inc.) at 1.16 nM final concentration was incubated with test compound ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent