BDBM788010 Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methylphenyl)-1-methylspiro[dihydroindole-3,4'-piperidine]-1'-carboxylate::US12473298, Compound 33

SMILES CCN(c1cc(-c2ccc3c(c2)N(C)CC32CCN(C(=O)OC)CC2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1

InChI Key InChIKey=YQWVGYCXWRNQKI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 788010   

TargetHistone-lysine N-methyltransferase EZH2 [Y641N](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788010BDBM788010(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.290nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788010BDBM788010(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.350nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788010BDBM788010(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.690nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788010BDBM788010(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.860nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent