BDBM788160 US12473303, Compound H-APPAMP-017

SMILES Cc1c(CNc2cc(NC[C@H]3CCNC[C@@H]3O)nc3c(C(C)C)cnn23)nc2ccccn12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 788160   

LigandChemical structure of BindingDB Monomer ID 788160BDBM788160(US12473303, Compound H-APPAMP-017)
Affinity DataIC50: 40nMAssay Description:(33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). All kinase assays were performed in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Carrick Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 788160BDBM788160(US12473303, Compound H-APPAMP-017)
Affinity DataIC50: 63nMAssay Description:(33PanQinase® Activity Assay) was used for measuring the kinase activity of the two protein kinases (CDK12/CDK7). All kinase assays were performed in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent