BDBM790078 2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 204

SMILES CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@H](C)CN(C1CC1)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 790078   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 790078BDBM790078(2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trim...)
Affinity DataIC50: 1.77nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 790078BDBM790078(2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trim...)
Affinity DataIC50: 1.85nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 790078BDBM790078(2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trim...)
Affinity DataIC50: 1.93nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 790078BDBM790078(2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trim...)
Affinity DataIC50: 2.53nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 790078BDBM790078(2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trim...)
Affinity DataIC50: 5.49nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 790078BDBM790078(2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trim...)
Affinity DataIC50: 5.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 790078BDBM790078(2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trim...)
Affinity DataIC50: 20.1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent