BDBM799578 6-(1-(methyl)-1Hpyrazol-4-yl)-4-(6-(6-((6-(methylsulfonyl)pyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile::US12583855, Example 76

SMILES Cn1cc(-c2cc(-c3ccc(N4CC5CC(C4)N5Cc4ccc(S(C)(=O)=O)nc4)nc3)c3c(C#N)cnn3c2)cn1

InChI Key InChIKey=VPAFNLGGTMQUPH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 799578   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 799578BDBM799578(6-(1-(methyl)-1Hpyrazol-4-yl)-4-(6-(6-((6-(methyls...)
Affinity DataIC50: 0.296nMAssay Description:The compounds in this invention inhibited the enzymatic activity of RETWT with IC50 values determined by homogeneous time-resolved fluorescence (HTRF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 799578BDBM799578(6-(1-(methyl)-1Hpyrazol-4-yl)-4-(6-(6-((6-(methyls...)
Affinity DataIC50: 0.479nMAssay Description:The compounds in this invention inhibited the enzymatic activity of RETV804M with IC50 values determined by homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 799578BDBM799578(6-(1-(methyl)-1Hpyrazol-4-yl)-4-(6-(6-((6-(methyls...)
Affinity DataIC50: 2.81nMAssay Description:The compounds in this invention inhibited the enzymatic activity of VEGFR2 with IC50 values determined by homogeneous time-resolved fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent