BDBM799580 6-(1-(difluoromethyl)-1Hpyrazol-4-yl)-4-(6-(6-((5-(methylsulfonyl)pyridin-2-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridine-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile::US12583855, Example 78

SMILES CS(=O)(=O)c1ccc(CN2C3CC2CN(c2ccc(-c4cc(-c5cnn(C(F)F)c5)cn5ncc(C#N)c45)cn2)C3)nc1

InChI Key InChIKey=RSXOUNBPHOAVSK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 799580   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 799580BDBM799580(6-(1-(difluoromethyl)-1Hpyrazol-4-yl)-4-(6-(6-((5-...)
Affinity DataIC50: 0.387nMAssay Description:The compounds in this invention inhibited the enzymatic activity of RETWT with IC50 values determined by homogeneous time-resolved fluorescence (HTRF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 799580BDBM799580(6-(1-(difluoromethyl)-1Hpyrazol-4-yl)-4-(6-(6-((5-...)
Affinity DataIC50: 1.04nMAssay Description:The compounds in this invention inhibited the enzymatic activity of RETV804M with IC50 values determined by homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Shouyao Holdings (Beijing) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 799580BDBM799580(6-(1-(difluoromethyl)-1Hpyrazol-4-yl)-4-(6-(6-((5-...)
Affinity DataIC50: 10.4nMAssay Description:The compounds in this invention inhibited the enzymatic activity of VEGFR2 with IC50 values determined by homogeneous time-resolved fluorescence (HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent