BDBM799682 US12583856, Example 174

SMILES Cc1c[nH]c2nccc(-c3ccc(C(=O)N[C@@H]4c5c(Cl)cccc5C[C@H]4N4CCCC4)cn3)c12

InChI Key InChIKey=NVGMZRKENWVTET-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 799682   

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Blueprint Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 799682BDBM799682(US12583856, Example 174)
Affinity DataIC50: 1nMAssay Description:PRKACA assay at Km: In each well of a 384-well plate, 0.007 ng/ul (0.18 nM) of PRKACA enzyme (Millipore: 539482) was incubated in a total of 12.5 μl ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/3/2026
Entry Details
US Patent