BDBM800331 8-(difluoromethoxy)-6-(6-(1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)benzofuran-3-yl)-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1 (2H)-one ::US20260085053, Example 40

SMILES O=C1c2c(cc(-c3coc4cc(-c5cnn(C6CCOC6)c5)ccc34)cc2OC(F)F)CCN1CC(F)(F)F

InChI Key InChIKey=SLJVTOAQPXZMRU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 800331   

TargetSerine/threonine-protein kinase SIK2(Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800331BDBM800331(8-(difluoromethoxy)-6-(6-(1-(tetrahydrofuran-3-yl)...)
Affinity DataIC50: 14nMAssay Description:Compounds were tested for inhibition of SIK2 kinase (full length, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3 [59-365](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800331BDBM800331(8-(difluoromethoxy)-6-(6-(1-(tetrahydrofuran-3-yl)...)
Affinity DataIC50: 31nMAssay Description:Compounds were tested for inhibition of SIK3 kinase (aa59-365, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy tran...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1 [1-303](Human)
Beone Medicines I

US Patent
LigandChemical structure of BindingDB Monomer ID 800331BDBM800331(8-(difluoromethoxy)-6-(6-(1-(tetrahydrofuran-3-yl)...)
Affinity DataIC50: 537nMAssay Description:Compounds were tested for inhibition of SIK1 kinase (aa1-303, Thermo Fisher) in assays based on the time-resolved fluorescence-resonance energy trans...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/5/2026
Entry Details
US Patent