BDBM801566 4-(4-Tosyl-3,4-dihydro-2H-pyrido[4,3-b][1,4]thiazin-8-yl)benzonitrile::US20260092074, Compound S12

SMILES Cc1ccc(S(=O)(=O)N2CCSc3c(-c4ccc(C#N)cc4)cncc32)cc1

InChI Key InChIKey=AFGCGTAJLUSJKE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 801566   

TargetCytochrome P450 11B2, mitochondrial(Human)
Guangzhou Vinnocent Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 801566BDBM801566(4-(4-Tosyl-3,4-dihydro-2H-pyrido[4,3-b][1,4]thiazi...)
Affinity DataIC50: 0.180nMAssay Description:Genes of human CYP11B2 and rat NADPH-P450 reductase were transfected into hamster V79 cells using a lentivirus vector, and stably-expressing cell lin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/12/2026
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou Vinnocent Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 801566BDBM801566(4-(4-Tosyl-3,4-dihydro-2H-pyrido[4,3-b][1,4]thiazi...)
Affinity DataIC50: 2.80nMAssay Description:Genes of human CYP11B1 and rat NADPH-P450 reductase were transfected into hamster V79 cells using a lentivirus vector, and stably-expressing cell lin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/12/2026
Entry Details
US Patent