BDBM801579 4-(4-(Pyridin-3-ylsulfonyl)-3,4-dihydro-2H-pyrido[4,3-b][1,4]thiazin-8-yl)benzonitrile::US20260092074, Compound S25

SMILES N#Cc1ccc(-c2cncc3c2SCCN3S(=O)(=O)c2cccnc2)cc1

InChI Key InChIKey=GELQAYWGRJOHGO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 801579   

TargetCytochrome P450 11B2, mitochondrial(Human)
Guangzhou Vinnocent Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 801579BDBM801579(4-(4-(Pyridin-3-ylsulfonyl)-3,4-dihydro-2H-pyrido[...)
Affinity DataIC50: 0.0400nMAssay Description:Genes of human CYP11B2 and rat NADPH-P450 reductase were transfected into hamster V79 cells using a lentivirus vector, and stably-expressing cell lin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/12/2026
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou Vinnocent Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 801579BDBM801579(4-(4-(Pyridin-3-ylsulfonyl)-3,4-dihydro-2H-pyrido[...)
Affinity DataIC50: 1.82nMAssay Description:Genes of human CYP11B1 and rat NADPH-P450 reductase were transfected into hamster V79 cells using a lentivirus vector, and stably-expressing cell lin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/12/2026
Entry Details
US Patent