BDBM808646 7-(2-fluoro-6-methyl-phenyl)-N5- [[(3S)-1-methylpyrrolidin-3- yl]methyl]isoquinoline-3,5-diamine::US12637428, Example E74

SMILES Cc1cccc(F)c1-c1cc(NC[C@@H]2CCN(C)C2)c2cc(N)ncc2c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808646   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808646BDBM808646(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3S)-1-methylpy...)
Affinity DataKi:  0.101nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808646BDBM808646(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3S)-1-methylpy...)
Affinity DataKi:  0.461nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808646BDBM808646(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3S)-1-methylpy...)
Affinity DataKi:  0.505nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808646BDBM808646(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3S)-1-methylpy...)
Affinity DataKi:  0.765nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808646BDBM808646(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3S)-1-methylpy...)
Affinity DataKi:  66.2nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808646BDBM808646(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3S)-1-methylpy...)
Affinity DataKi: >1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent