BDBM81347 L2037 (beta-lapachone)

SMILES CN(c1ccc(c(c1)O)O)N=O

InChI Key InChIKey=XAKAQCMEMMZUEO-UHFFFAOYSA-N

Data  4 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 81347   

TargetProtein-glutamine gamma-glutamyltransferase 2(Human)
Duke University Medical Center

LigandPNGBDBM81347(L2037 (beta-lapachone))
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:In order to eliminated fluorescence interference, chemicals were subjected to a secondary screening using colorimetric BP incorporation assay. TGase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2011
Entry Details Article
PubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Human)
Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM81347(L2037 (beta-lapachone))
Affinity DataIC50: 500nMAssay Description:Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
Siberian Branch of The Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM81347(L2037 (beta-lapachone))
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant human Tdp1 using 5'-biotin-GATCTAAAAGACTT-pY-3' as substrate measured after 20 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
Siberian Branch of The Russian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM81347(L2037 (beta-lapachone))
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant TDP1 (unknown origin) using 5'-32P-labeled N14Y DNA substrate incubated for 20 mins by PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed