BDBM8386 CHEMBL260243::N-[6-(furan-3-yl)-1H-indazol-3-yl]cyclopropanecarboxamide::indazole analogue 28

SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccoc1)C1CC1

InChI Key InChIKey=XOCIRJMUBXHWBK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8386   

TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8386(N-[6-(furan-3-yl)-1H-indazol-3-yl]cyclopropanecarb...)
Affinity DataIC50: 35nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8386(N-[6-(furan-3-yl)-1H-indazol-3-yl]cyclopropanecarb...)
Affinity DataIC50: 1.00E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM8386(N-[6-(furan-3-yl)-1H-indazol-3-yl]cyclopropanecarb...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8386(N-[6-(furan-3-yl)-1H-indazol-3-yl]cyclopropanecarb...)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed