BDBM8387 CHEMBL318522::N-[6-(thiophen-2-yl)-1H-indazol-3-yl]cyclopropanecarboxamide::indazole analogue 29

SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1cccs1)C1CC1

InChI Key InChIKey=GWTAEVKZCDFFEX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8387   

TargetGlycogen synthase kinase-3 alpha(Human)
Glaxosmithkline

LigandPNGBDBM8387(N-[6-(thiophen-2-yl)-1H-indazol-3-yl]cyclopropanec...)
Affinity DataIC50: 215nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8387(N-[6-(thiophen-2-yl)-1H-indazol-3-yl]cyclopropanec...)
Affinity DataIC50: 341nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM8387(N-[6-(thiophen-2-yl)-1H-indazol-3-yl]cyclopropanec...)
Affinity DataIC50: 341nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Jordan

Curated by ChEMBL
LigandPNGBDBM8387(N-[6-(thiophen-2-yl)-1H-indazol-3-yl]cyclopropanec...)
Affinity DataIC50: 215nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed