BDBM85097 CAS_181632-25-7::CHEMBL14563::SB 242084

SMILES Cc1cc2CCN(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2cc1Cl

InChI Key InChIKey=GIUZEIJUFOPTMR-UHFFFAOYSA-N

Data  30 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 41 hits for monomerid = 85097   

Target5-hydroxytryptamine receptor 2C(Human)
Dominican College

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 0.330nMAssay Description:Antagonist activity at recombinant human 5-HT2C expressed in human U2OS cells by pathhunter beta-arrestin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human Cytochrome P450 1A2 at 500 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human Cytochrome P450 3A at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human Cytochrome P450 2D6 at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human Cytochrome P450 2C9 at 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human cytochrome P450 1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human Cytochrome P450 19A1 at 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human cytochrome P450 2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human cytochrome P450 2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human cytochrome P450 3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of heterologously expressed human cytochrome P450 2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]mesulergine from 5HT2C in Sprague-Dawley rat whole brain membranes after 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Dominican College

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  0.480nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Dominican College

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  1nMAssay Description:Binding affinity for human 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells using [3H]mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Dominican College

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Dominican College

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  1nMAssay Description:Binding affinity towards human cloned 5-hydroxytryptamine receptor 2C in HEK293 cells, using [3H]mesulergine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Dominican College

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  1nMAssay Description:Binding affinity towards human cloned 5-hydroxytryptamine 2C receptor of HEK293 cells by displacement of [3H]mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Dominican College

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  7.08nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  45.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  100nMAssay Description:Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  100nMAssay Description:Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  100nMAssay Description:Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  145nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  158nMAssay Description:Binding affinity towards human cloned 5-hydroxytryptamine 2A receptor of HEK293 cells by displacement of [3H]ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  158nMAssay Description:Binding affinity towards human cloned 5-hydroxytryptamine receptor 2A in HEK293 cells, using [3H]ketanserin as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  158nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  158nMAssay Description:Binding affinity for human 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells using [3H]ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  274nMAssay Description:Displacement of [3H]ketanserin from 5HT2A in Wistar rat frontal cortex membranes after 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Chinese hamster)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  398nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Chinese hamster)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  398nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Chinese hamster)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  631nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Golden hamster)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  631nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  794nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Chinese hamster)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  794nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  851nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
TargetG_PROTEIN_RECEP_F1_2 domain-containing protein(Chinese hamster)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat whole brain membranes after 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2017
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Pig)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi:  3.16E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85097(CAS_181632-25-7 | CHEMBL14563 | SB 242084)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details Article
PubMed