BDBM8639 (isoquinolinemethylene)indane 30a::5-{[(1E)-5-fluoro-2,3-dihydro-1H-inden-1-ylidene]methyl}isoquinoline

SMILES Fc1ccc2\C(CCc2c1)=C\c1cccc2cnccc12

InChI Key InChIKey=RNIVQRPDPOQWHP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 8639   

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM8639(5-{[(1E)-5-fluoro-2,3-dihydro-1H-inden-1-ylidene]m...)
Affinity DataIC50: 1.13E+3nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

LigandPNGBDBM8639(5-{[(1E)-5-fluoro-2,3-dihydro-1H-inden-1-ylidene]m...)
Affinity DataIC50: 58nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Saarland University

LigandPNGBDBM8639(5-{[(1E)-5-fluoro-2,3-dihydro-1H-inden-1-ylidene]m...)
Affinity DataIC50: 720nMAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Saarland University

LigandPNGBDBM8639(5-{[(1E)-5-fluoro-2,3-dihydro-1H-inden-1-ylidene]m...)
Affinity DataIC50: 720nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Saarland University

LigandPNGBDBM8639(5-{[(1E)-5-fluoro-2,3-dihydro-1H-inden-1-ylidene]m...)
Affinity DataIC50: 720nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed