BDBM8826 3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-methylphenyl)urea::Biochemistry 469551 Compound 3::CHEMBL196363::KDR Kinase Inhibitor, 1::N-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N -(3-methylphenyl)urea::Thienopyrimidine deriv. 76

SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1

InChI Key InChIKey=DZSUJUOJJJCWGG-UHFFFAOYSA-N

Data  4 KI  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 8826   

TargetVascular endothelial growth factor receptor 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 13nMAssay Description:Inhibition of FLT4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 3.02nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 724nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 6.03nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 6nMAssay Description:Inhibition of c-Kit by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CKITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 730nMAssay Description:Inhibition of TIE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 1nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 3nMAssay Description:Inhibition assay using KDR.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2011
Entry Details Article
PubMed
TargetAromatase(Human)
Abbott Laboratories

LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 720nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Dalian University

Curated by ChEMBL
LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataIC50: 6nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Abbott Laboratories

LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataKi:  64nM ΔG°:  -9.71kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Abbott Laboratories

LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataKi:  130nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataKi:  210nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Abbott Laboratories

LigandPNGBDBM8826(CHEMBL196363 | 3-(4-{4-aminothieno[2,3-d]pyrimidin...)
Affinity DataKi: >2.00E+4nM ΔG°: >-6.34kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed